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SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.6
USERS' SCORE
Good
Based on 6 Reviews
8.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
8
Eicosapentaenoic acid benefits MS
The therapeutic effect of PEGlated nanoliposome of pistachio unsaturated oils and its efficacy to attenuate inflammation in multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial phase I.
Directly addresses eicosapentaenoic acid
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore the effects of PEGlated nanoliposome of pistachio unsaturated oils on inflammation in multiple sclerosis (MS). During the study, we treated MS patients with these nanoliposomes enriched with eicosapentaenoic acid, a type of omega-3 fatty acid known for its potential health benefits.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.
Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
Read More
9
DHA shows promise for autoimmunity
Neuroprotective and antioxidant effects of docosahexaenoic acid (DHA) in an experimental model of multiple sclerosis.
Direct impact on autoimmune disorder
We conducted a study to evaluate how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, can impact autoimmune disorders, specifically using an animal model of multiple sclerosis (MS). In this investigation, we worked with twenty-five Dark Agouti rats, dividing them into distinct groups. Some received DHA, while others served as controls, allowing for comparisons of its effectiveness on clinical symptoms and levels of oxidative stress.
Over the course of 51 days, DHA was administered via injections, with a daily 40 mg/kg dosage given five days a week. What we observed was quite encouraging. The DHA supplementation appeared to lead to a reduction in oxidative stress markers and showed improvements in clinical scores related to the disease. These results suggest that DHA has the potential to positively influence the progression of MS.
Furthermore, we believe this effect may be linked to DHA’s ability to activate Nrf2, an important antioxidant factor in our bodies. Overall, our findings indicate that DHA could be a beneficial treatment option for managing multiple sclerosis and possibly other autoimmune conditions.
Over the course of 51 days, DHA was administered via injections, with a daily 40 mg/kg dosage given five days a week. What we observed was quite encouraging. The DHA supplementation appeared to lead to a reduction in oxidative stress markers and showed improvements in clinical scores related to the disease. These results suggest that DHA has the potential to positively influence the progression of MS.
Furthermore, we believe this effect may be linked to DHA’s ability to activate Nrf2, an important antioxidant factor in our bodies. Overall, our findings indicate that DHA could be a beneficial treatment option for managing multiple sclerosis and possibly other autoimmune conditions.
Read More
9
DHA triggers cell death in RA
DHA Induces Cell Death through the Production of ROS and the Upregulation of CHOP in Fibroblast-like Synovial Cells from Human Rheumatoid Arthritis Patients.
Highly relevant to autoimmune RA
We explored the effects of docosahexaenoic acid (DHA) on fibroblast-like synovial cells from patients with rheumatoid arthritis (RA). Our study demonstrated that DHA prompted cells to undergo apoptosis, or programmed cell death, particularly through a process dependent on caspase-8. This occurred in a dose-dependent manner, suggesting that higher amounts of DHA resulted in greater cell death.
Additionally, we observed that DHA was effective in reducing inflammation markers, such as MMP-9 and IL-1β, which are often heightened in autoimmune conditions like RA. The treatment also triggered important cellular responses, including the activation of endoplasmic reticulum (ER) stress markers like CHOP.
We discovered that lowering levels of CHOP or another protein called DR5 improved cell survival and diminished DHA-induced apoptosis. Importantly, our findings revealed that DHA led to an accumulation of reactive oxygen species (ROS), which are harmful byproducts that can damage cells. When we treated cells with an antioxidant, we found that it significantly reduced the expression of both CHOP and DR5, as well as the associated cell death.
Our results were consistent across both laboratory cell lines and primary synovial cells directly obtained from RA patients. This suggests that DHA may offer a new avenue for treatment by harnessing the body's cellular responses to combat the destructive processes of RA.
Additionally, we observed that DHA was effective in reducing inflammation markers, such as MMP-9 and IL-1β, which are often heightened in autoimmune conditions like RA. The treatment also triggered important cellular responses, including the activation of endoplasmic reticulum (ER) stress markers like CHOP.
We discovered that lowering levels of CHOP or another protein called DR5 improved cell survival and diminished DHA-induced apoptosis. Importantly, our findings revealed that DHA led to an accumulation of reactive oxygen species (ROS), which are harmful byproducts that can damage cells. When we treated cells with an antioxidant, we found that it significantly reduced the expression of both CHOP and DR5, as well as the associated cell death.
Our results were consistent across both laboratory cell lines and primary synovial cells directly obtained from RA patients. This suggests that DHA may offer a new avenue for treatment by harnessing the body's cellular responses to combat the destructive processes of RA.
Read More
Most Useful Reviews
9.5
Supports brain health
Omega 3 from Now has a high concentration of DHA, which I use according to the Nemechek protocol for brain recovery and to suppress inflammatory processes. DHA is crucial for brain function and cognitive development, especially as half of a mother's DHA reserve is passed to the child during pregnancy. Since DHA significantly exceeds EPA in the brain, it’s essential for mental nutrition. Now's Omega 3 is ideal for adults needing high DHA concentrations.
Read More
9.5
Improved mental performance
Omega-3 is essential for my brain health, particularly DHA, which I realised I needed due to my poor diet. Since taking DHA-500 along with fish oil, I've noticed significant improvements in memory, brain function, and even my hair and skin condition. I plan to continue this supplementation indefinitely, as I am now aware of its vital role in cognitive performance and mood support, especially given the prevalence of depression today.
Read More
9.5
Significant health improvement
Consuming this product has greatly improved my health. I discovered it through a health group focused on autoimmune disorders during a challenging time. Since I started taking it, my condition has improved, and my symptoms have noticeably decreased.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.6
9
DHA mediators reduce RA symptoms
Lipid mediators obtained from docosahexaenoic acid by soybean lipoxygenase attenuate RANKL-induced osteoclast differentiation and rheumatoid arthritis.
Mixed effects observed in study
We explored how lipid mediators derived from docosahexaenoic acid (DHA) impact rheumatoid arthritis (RA), an autoimmune disorder marked by inflammation and joint damage. In our investigation, we noted that a specific combination of lipid mediators produced from DHA, including 17S-monohydroxy docosahexaenoic acid, resolvin D5, and protectin DX, showed promise in reducing arthritis severity.
The study involved using collagen antibody-induced arthritis (CAIA) in mice and examining RANKL-induced osteoclast formation using RAW264.7 cells. We observed that these lipid mediators effectively lowered the expression of certain markers related to osteoclast formation. They also showed potential by suppressing inflammatory pathways within cells.
In addition to promising laboratory results, our findings indicated that mice treated with these lipid mediators exhibited significantly less swelling and inflammation in their paws. We noticed a decrease in inflammatory cytokines in their serum, which is crucial for managing autoimmune responses, while levels of an anti-inflammatory cytokine, IL-10, increased.
These findings suggest that the lipid mediators derived from DHA can alleviate joint inflammation and damage associated with rheumatoid arthritis, indicating their potential as a therapeutic option. Overall, our research highlights the positive effects of DHA-related lipid mediators on autoimmune disorders like RA.
The study involved using collagen antibody-induced arthritis (CAIA) in mice and examining RANKL-induced osteoclast formation using RAW264.7 cells. We observed that these lipid mediators effectively lowered the expression of certain markers related to osteoclast formation. They also showed potential by suppressing inflammatory pathways within cells.
In addition to promising laboratory results, our findings indicated that mice treated with these lipid mediators exhibited significantly less swelling and inflammation in their paws. We noticed a decrease in inflammatory cytokines in their serum, which is crucial for managing autoimmune responses, while levels of an anti-inflammatory cytokine, IL-10, increased.
These findings suggest that the lipid mediators derived from DHA can alleviate joint inflammation and damage associated with rheumatoid arthritis, indicating their potential as a therapeutic option. Overall, our research highlights the positive effects of DHA-related lipid mediators on autoimmune disorders like RA.
Read More
9
DHA shows promise for autoimmunity
Neuroprotective and antioxidant effects of docosahexaenoic acid (DHA) in an experimental model of multiple sclerosis.
Direct impact on autoimmune disorder
We conducted a study to evaluate how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, can impact autoimmune disorders, specifically using an animal model of multiple sclerosis (MS). In this investigation, we worked with twenty-five Dark Agouti rats, dividing them into distinct groups. Some received DHA, while others served as controls, allowing for comparisons of its effectiveness on clinical symptoms and levels of oxidative stress.
Over the course of 51 days, DHA was administered via injections, with a daily 40 mg/kg dosage given five days a week. What we observed was quite encouraging. The DHA supplementation appeared to lead to a reduction in oxidative stress markers and showed improvements in clinical scores related to the disease. These results suggest that DHA has the potential to positively influence the progression of MS.
Furthermore, we believe this effect may be linked to DHA’s ability to activate Nrf2, an important antioxidant factor in our bodies. Overall, our findings indicate that DHA could be a beneficial treatment option for managing multiple sclerosis and possibly other autoimmune conditions.
Over the course of 51 days, DHA was administered via injections, with a daily 40 mg/kg dosage given five days a week. What we observed was quite encouraging. The DHA supplementation appeared to lead to a reduction in oxidative stress markers and showed improvements in clinical scores related to the disease. These results suggest that DHA has the potential to positively influence the progression of MS.
Furthermore, we believe this effect may be linked to DHA’s ability to activate Nrf2, an important antioxidant factor in our bodies. Overall, our findings indicate that DHA could be a beneficial treatment option for managing multiple sclerosis and possibly other autoimmune conditions.
Read More
9
DHA's Role in Treg Differentiation
Fatty acid desaturation by stearoyl-CoA desaturase-1 controls regulatory T cell differentiation and autoimmunity.
High relevance to Treg differentiation
We investigated how docosahexaenoic acid (DHA), a key fatty acid, influences autoimmune disorders like multiple sclerosis (MS). Our findings revealed that fatty acid metabolism, particularly through the enzyme stearoyl-CoA desaturase-1 (SCD1), plays a critical role in the differentiation of regulatory T cells (Tregs), which are important for maintaining immune balance.
The absence of SCD1 in T cells leads to increased hydrolysis of triglycerides and phosphatidylcholine. This process, facilitated by an enzyme known as adipose triglyceride lipase (ATGL), results in the release of DHA, which further enhances Treg differentiation. By activating the nuclear receptor known as peroxisome proliferator-activated receptor gamma, DHA helps promote a more robust Treg population, potentially reducing the risk of autoimmune reactions.
Our exploration underscores the significance of dietary fatty acids in regulating immune responses. By highlighting DHA's role in modulating Treg differentiation and its potential implications for treating autoimmune conditions, this study paves the way for future dietary interventions and therapeutic strategies aimed at controlling autoimmune disorders like MS.
The absence of SCD1 in T cells leads to increased hydrolysis of triglycerides and phosphatidylcholine. This process, facilitated by an enzyme known as adipose triglyceride lipase (ATGL), results in the release of DHA, which further enhances Treg differentiation. By activating the nuclear receptor known as peroxisome proliferator-activated receptor gamma, DHA helps promote a more robust Treg population, potentially reducing the risk of autoimmune reactions.
Our exploration underscores the significance of dietary fatty acids in regulating immune responses. By highlighting DHA's role in modulating Treg differentiation and its potential implications for treating autoimmune conditions, this study paves the way for future dietary interventions and therapeutic strategies aimed at controlling autoimmune disorders like MS.
Read More
9
DHA triggers cell death in RA
DHA Induces Cell Death through the Production of ROS and the Upregulation of CHOP in Fibroblast-like Synovial Cells from Human Rheumatoid Arthritis Patients.
Highly relevant to autoimmune RA
We explored the effects of docosahexaenoic acid (DHA) on fibroblast-like synovial cells from patients with rheumatoid arthritis (RA). Our study demonstrated that DHA prompted cells to undergo apoptosis, or programmed cell death, particularly through a process dependent on caspase-8. This occurred in a dose-dependent manner, suggesting that higher amounts of DHA resulted in greater cell death.
Additionally, we observed that DHA was effective in reducing inflammation markers, such as MMP-9 and IL-1β, which are often heightened in autoimmune conditions like RA. The treatment also triggered important cellular responses, including the activation of endoplasmic reticulum (ER) stress markers like CHOP.
We discovered that lowering levels of CHOP or another protein called DR5 improved cell survival and diminished DHA-induced apoptosis. Importantly, our findings revealed that DHA led to an accumulation of reactive oxygen species (ROS), which are harmful byproducts that can damage cells. When we treated cells with an antioxidant, we found that it significantly reduced the expression of both CHOP and DR5, as well as the associated cell death.
Our results were consistent across both laboratory cell lines and primary synovial cells directly obtained from RA patients. This suggests that DHA may offer a new avenue for treatment by harnessing the body's cellular responses to combat the destructive processes of RA.
Additionally, we observed that DHA was effective in reducing inflammation markers, such as MMP-9 and IL-1β, which are often heightened in autoimmune conditions like RA. The treatment also triggered important cellular responses, including the activation of endoplasmic reticulum (ER) stress markers like CHOP.
We discovered that lowering levels of CHOP or another protein called DR5 improved cell survival and diminished DHA-induced apoptosis. Importantly, our findings revealed that DHA led to an accumulation of reactive oxygen species (ROS), which are harmful byproducts that can damage cells. When we treated cells with an antioxidant, we found that it significantly reduced the expression of both CHOP and DR5, as well as the associated cell death.
Our results were consistent across both laboratory cell lines and primary synovial cells directly obtained from RA patients. This suggests that DHA may offer a new avenue for treatment by harnessing the body's cellular responses to combat the destructive processes of RA.
Read More
9
DHA's potential in autoimmune therapy
Role of omega-3 endocannabinoids in the modulation of T-cell activity in a multiple sclerosis experimental autoimmune encephalomyelitis (EAE) model.
Relevance to dietary treatment strategies
We explored how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects autoimmune disorders like multiple sclerosis (MS). The study focused on an experimental model known as relapse-remitting experimental autoimmune encephalomyelitis (RR-EAE), which is commonly used to understand MS better.
Through our investigation, we found that DHA can be transformed into beneficial metabolites. One such metabolite, docosahexaenoyl ethanolamide (DHEA), was observed to lessen the polarization of immune cells, specifically naïve T-cells, towards proinflammatory types that can exacerbate autoimmune issues. This means that DHEA could help keep the immune response in check.
Moreover, we noticed that the levels of DHEA and related compounds changed as the disease progressed in the mice. Interestingly, when we administered DHEA daily to these mice, it delayed the onset of symptoms, slowed down relapses, and reduced the severity of clinical scores.
Overall, our findings suggest that DHEA and its metabolites may play a protective role in autoimmune disorders like MS and could serve as a promising nutritional complement to current treatments.
Through our investigation, we found that DHA can be transformed into beneficial metabolites. One such metabolite, docosahexaenoyl ethanolamide (DHEA), was observed to lessen the polarization of immune cells, specifically naïve T-cells, towards proinflammatory types that can exacerbate autoimmune issues. This means that DHEA could help keep the immune response in check.
Moreover, we noticed that the levels of DHEA and related compounds changed as the disease progressed in the mice. Interestingly, when we administered DHEA daily to these mice, it delayed the onset of symptoms, slowed down relapses, and reduced the severity of clinical scores.
Overall, our findings suggest that DHEA and its metabolites may play a protective role in autoimmune disorders like MS and could serve as a promising nutritional complement to current treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.7
9.5
Supports brain health
Omega 3 from Now has a high concentration of DHA, which I use according to the Nemechek protocol for brain recovery and to suppress inflammatory processes. DHA is crucial for brain function and cognitive development, especially as half of a mother's DHA reserve is passed to the child during pregnancy. Since DHA significantly exceeds EPA in the brain, it’s essential for mental nutrition. Now's Omega 3 is ideal for adults needing high DHA concentrations.
Read More
9.5
Enhanced overall wellbeing
This is the best omega I’ve tried. With a double dose at a great price, my husband and I have taken it for 3 months. We've noticed much improvement - fatigue and sleepiness disappeared, and our concentration and memory improved significantly. After my third pregnancy, my joint issues returned to normal. I happily recommend it and will order again. It has no unpleasant smell, and although the capsules are large, they’re easy to swallow.
Read More
9.5
Improved mental performance
Omega-3 is essential for my brain health, particularly DHA, which I realised I needed due to my poor diet. Since taking DHA-500 along with fish oil, I've noticed significant improvements in memory, brain function, and even my hair and skin condition. I plan to continue this supplementation indefinitely, as I am now aware of its vital role in cognitive performance and mood support, especially given the prevalence of depression today.
Read More
9.5
Significant health improvement
Consuming this product has greatly improved my health. I discovered it through a health group focused on autoimmune disorders during a challenging time. Since I started taking it, my condition has improved, and my symptoms have noticeably decreased.
9.5
Consistent positive results
Excellent omega! This is my repeated order. The results are noticeable, and I feel much better.
